apalutamide will reduce the level or result of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP2C19 inducer, with medication which are CYP2C19 substrates can lead to reduce exposure to those medicines.diazepam will boost the stage or effect of ruxolitinib by in